Perforation of chronic peptic ulcers after cimetidine.

Cimetidine for ulcers recurring after gastric surgery.

Treatment of 'cimetidine-resistant' chronic duodenal ulcers with ranitidine or cimetidine: a randomised multicentre study.

Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of 21 given ranitidine (62%); two patients on cimetidine and two on ranitidine d...

Ultrastructural changes in gastric ulcers after bicitropeptide and cimetidine treatment.

Ultrastructural studies were conducted on biopsy specimens taken by endoscopy from the edge of gastric ulcers in the distal part of the stomach of 9 patients before and after treatment with either bicitropeptide or cimetidine. Marked depletion of mucin granules in the mucous epithelial cells and the pyloric gland cells was found in all patients and there was morphological evidence of a block in...

Intravenous omeprazole after endoscopic treatment of bleeding peptic ulcers.

Comment Active ulcer bleeding can usually be stopped by therapeutic endoscopy but 15–20% of patients rebleed, usually within the first 24 hours. The rebleeding rate is similar for all endoscopic haemostatic modalities and combinations of endoscopic treatments are little better than single modalities. Patients who rebleed have a high risk of dying. Rebleeding occurs as the blood clot which is fo...

Posterior perforation of peptic ulcers: presentation and outcome of an uncommon surgical emergency.

BACKGROUND Posterior perforation of peptic ulcer is a distinct clinical entity not commonly encountered. This report evaluates the presentation, diagnosis, management, and outcome of this acute surgical condition. METHODS We reviewed records of 9 patients with posterior perforations who were treated at our institution from January 1990 to June 2002. RESULTS This condition was characterized ...